Interplay Between Statins, Cav1 (Caveolin-1), and Aldosterone
نویسندگان
چکیده
منابع مشابه
Association Between Rs3807989 Polymorphism in Caveolin-1 (CAV1) Gene and Atrial Fibrillation: A Meta-Analysis
BACKGROUND Atrial fibrillation (AF) is the most common sustained arrhythmia affected by multiple cardiovascular risk factors. It is reported that caveolin-1 gene (CAV1) rs3807989 polymorphism might be associated with AF risk. The goal of this meta-analysis was to confirm the association between CAV1 rs3807989 polymorphism and susceptibility to AF. MATERIAL AND METHODS We carried out a comprehen...
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The mitochondria-associated membrane (MAM) is a specialized subdomain of the endoplasmic reticulum (ER) which acts as an intracellular signaling hub. MAM dysfunction has been related to liver disease. We report a high-throughput mass spectrometry-based proteomics characterization of MAMs from mouse liver, which portrays them as an extremely complex compartment involved in different metabolic pr...
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BACKGROUND Identification of the culprit genes underlying multifactorial diseases is one of the most important current challenges of molecular genetics. While recent advances in genomics research have accelerated the discovery of susceptibility genes, much remains to be learned about the functions of disease-associated genetic variants. Recently, Moore and co-workers identified, in the donor ge...
متن کاملgenotypic frequency of caveolin-1 (cav1) t29107a polymorphism in the iranian patients with breast cancer
introduction: caveolin-1 (cav-1) is a scaffolding protein found in special structures of plasma membrane, known as caveolae. cav-1 can regulate many intracellular processes, including signal transmission and cholesterol metabolism. this protein plays an important role in the growth and differentiation of breast tissue and acts as a tumor suppressor gene as well. the aim of this study was to det...
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BACKGROUND Overactivation of the aldosterone and mineralocorticoid receptor (MR) pathway is associated with hyperglycemia and dyslipidemia. Caveolin 1 (cav-1) is involved in glucose/lipid homeostasis and may modulate MR signaling. We investigated the interplay between cav-1 and aldosterone signaling in modulating insulin resistance and dyslipidemia in cav-1-null mice and humans with a prevalent...
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ژورنال
عنوان ژورنال: Hypertension
سال: 2020
ISSN: 0194-911X,1524-4563
DOI: 10.1161/hypertensionaha.120.14777